The Method IP 346 was developed by Shell scientists as a chemical screening assay for dermal carcinogenicity. Like the Modified Ames Test, it relies on the fact that the principal carcinogens in oils are PAC, and that the biologically active members of the class are readily extractable into dimethyl sulfoxide (DMSO).

The Method IP 346 was developed by Shell scientists as a chemical screening assay for dermal carcinogenicity. Like the Modified Ames Test, it relies on the fact that the principal carcinogens in oils are PAC, and that the biologically active members of the class are readily extractable into dimethyl sulfoxide (DMSO).

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